Closed-loop Continuous Infusions of Etomidate and Etomidate Analogs in Rats

Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function.

BACKGROUND Etomidate is a sedative-hypnotic that is often given as a single intravenous bolus but rarely as an infusion because it suppresses adrenocortical function. Methoxycarbonyl etomidate and (R)-ethyl 1-(1-phenylethyl)-1H-pyrrole-2-carboxylate (carboetomidate) are etomidate analogs that do not produce significant adrenocortical suppression when given as a single bolus. However, the effect...

Etomidate in Emergency Medicine

Etomidate and treatment propensity.

1128 November 2014 To the Editor: Wagner et al.1 must be congratulated for their robust and interesting work into the effects of a single dose of etomidate on long-term outcomes. Nonetheless, we consider that several elements would benefit from greater information and discussion. First, the doses of etomidate administered were not reported and therefore any dose–response effect remains unclear;...

Respiratory effects of etomidate.

The respiratory effects of etomidate 0.3 mg/kg were studied in patients premedicated with either diazepam and atropine or papaveretum and hyoscine. The incidence of apnoea was 40% in those who received the non-narcotic premedication, compared with 27% in those who received the opiate. Those premedicated with diazepam and atropine showed a significant increase in respiratory frequency which was ...

Etomidate as an antiarrhythmic.

Editor—We wish to report a case of etomidate reverting ventricular tachycardia to sinus rhythm. Although there have been several case reports and studies demonstrating the antiarrhythmic affects of propofol this has not been true of etomidate. A 59-yr-old man presented to the emergency department with a 2 h history of central chest pain radiating to the left arm and palpitations. He denied any ...